A complete list of publications from the Ressler Lab can be found on Pubmed, ResearchGate, or Google Scholar.
Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy.
Seligowski AV, Misganaw B, Duffy LA, Ressler KJ, Guffanti G. Am J Psychiatry. 2022 Sep 7:appiajp21111113. doi: 10.1176/appi.ajp.21111113. Epub ahead of print. PMID: 36069022.
Persistent Dissociation and Its Neural Correlates in Predicting Outcomes After Trauma Exposure.
Lebois LAM, Harnett NG, van Rooij SJH, Ely TD, Jovanovic T... Ressler KJ. Am J Psychiatry. 2022 Sep;179(9):661-672.
Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis.
Harnett NG, Finegold KE, Lebois LAM, van Rooij SJH, Ely TD...Ressler KJ, Stevens JS. Transl Psychiatry. 2022 Aug 8;12(1):321.
Neurotensin orchestrates valence assignment in the amygdala.
Li H, Namburi P, Olson JM, Borio M, Lemieux ME, Beyeler A...Ressler KJ, Fiete IR, Zhang F, Li Y, Tye KM. Nature. 2022 Aug;608(7923):586-592.
PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus.
Velasco ER, Florido A, Flores Á, Senabre E, Gomez-Gomez A...Ressler KJ, Garcia-Esteve LL, Jovanovic T, Andero R. Nat Commun. 2022 Jul 28;13(1):4374.
Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits.
Ressler KJ, Berretta S, Bolshakov VY, Rosso IM, Meloni EG, Rauch SL, Carlezon WA Jr. Nat Rev Neurol. 2022 May;18(5):273-288.
Racial Discrimination and White Matter Microstructure in Trauma-Exposed Black Women.
Fani N, Harnett NG, Bradley B, Mekawi Y, Powers A, Stevens JS, Ressler KJ, Carter SE. Biol Psychiatry. 2022 Feb 1;91(3):254-261.
Amygdala DCX and blood Cdk14 are implicated as cross-species indicators of individual differences in fear, extinction, and resilience to trauma exposure.
Maheu ME, Sharma S, King G, Maddox SA, Wingo A...Ressler KJ. Mol Psychiatry. 2022 Feb;27(2):956-966.
Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma.
Stevens JS, Harnett NG, Lebois LAM, van Rooij SJH, Ely TD...Ressler KJ. Am J Psychiatry. 2021 Nov;178(11):1037-1049.
Association of Racial Discrimination With Neural Response to Threat in Black Women in the US Exposed to Trauma.
Fani N, Carter SE, Harnett NG, Ressler KJ, Bradley B. JAMA Psychiatry. 2021 Sep 1;78(9):1005-1012.
Deep Transcranial Magnetic Stimulation Combined With Brief Exposure for Posttraumatic Stress Disorder: A Prospective Multisite Randomized Trial.
Isserles M, Tendler A, Roth Y, Bystritsky A, Blumberger DM...Ressler KJ.Biol Psychiatry. 2021 Nov 15;90(10):721-728.
Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5.
Hartmann J, Bajaj T, Klengel C, Chatzinakos C, Ebert T, Dedic N...Ressler KJ. Cell Rep. 2021 Jun 1;35(9):109185.
Integration of peripheral transcriptomics, genomics, and interactomics following trauma identifies causal genes for symptoms of post-traumatic stress and major depression.
Wuchty S, Myers AJ, Ramirez-Restrepo M, Huentelman M, Richolt R... Ressler KJ, Nemeroff CB. Mol Psychiatry. 2021 Jul;26(7):3077-3092.
Nucleus Accumbens Medium Spiny Neuron Subtypes Differentially Regulate Stress-Associated Alterations in Sleep Architecture. McCullough KM, Missig G, Robble MA, Foilb AR, Wells AM...Ressler KJ, Carlezon WA Jr. Biol Psychiatry. 2021 Jun 15;89(12):1138-1149.
Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning.
McCullough KM, Chatzinakos C, Hartmann J, Missig G, Neve RL...Ressler KJ. Nat Commun. 2020 Oct 14;11(1):5180.
Association of Prospective Risk for Chronic PTSD Symptoms With Low TNFα and IFNγ Concentrations in the Immediate Aftermath of Trauma Exposure.
Michopoulos V, Beurel E, Gould F, Dhabhar FS, Schultebraucks K...Ressler KJ, Nemeroff CB. Am J Psychiatry. 2020 Jan 1;177(1):58-65.
Translating Across Circuits and Genetics Toward Progress in Fear- and Anxiety-Related Disorders.
Ressler KJ. Am J Psychiatry. 2020 Mar 1;177(3):214-222.
A validated predictive algorithm of post-traumatic stress course following emergency department admission after a traumatic stressor.
Schultebraucks K, Shalev AY, Michopoulos V, ... Ressler KJ, Galatzer-Levy IR. Nature Med. 2020 Jul;26(7):1084-1088.
Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts.
Huckins LM, Chatzinakos C, Breen MS, Hartmann J, Klengel T, ... Ressler KJ, Stahl EA, Daskalakis NP. Cell Reports. 2020 Jun 2;31(9):107716.
Pre-deployment risk factors for PTSD in active-duty personnel deployed to Afghanistan: a machine-learning approach for analyzing multivariate predictors.
Schultebraucks K, Qian M, ... Ressler KJ, Doyle FJ 3rd, Jett M, Marmar CR. Molecular Psychiatry. 2020 Jun 2.
The glucocorticoid receptor-FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder.
Li H, Su P, Lai TK, Jiang A, Liu J, Zhai D, Campbell CT, Lee FH, Yong W, Pasricha S, Li S, Wong AH, Ressler KJ, Liu F. J Clin Invest. 2020 Feb 3;130(2):877-889.
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.
Nievergelt CM, Maihofer AX, Klengel T, ... Ressler KJ, Haas M, Koenen KC. Nature Commun. 2019 Oct 8;10(1):4558.
Deconstructing the gestalt: mechanisms of fear, threat, and trauma memory encoding.
Maddox SA, Hartman J, Ross RA, Ressler KJ. Neuron. 2019 Apr 3; 102:60. doi: 10.1016/j.neuron.2019.03.017
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.
Dedic N, Kühne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, Pöhlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM. Nature Neuroscience. 2018 Jun; 21:803.
Reversing behavioral, neuroanatomical, and germline influences of intergenerational stress.
Aoued HS, Sannigrahi S, Doshi N, Morrison FG, Linsenbaum H, Hunter SC, Walum H, Baman J, Yao B, Jin P, Ressler KJ, Dias BG. Biological Psychiatry. 2019 Feb 1; 85:248.
Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man.
Fenster RJ, Lebois LAM, Ressler KJ, Suh J. Nature Reviews Neuroscience. 2018 Sep; 19:535.
Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.
Duncan LE, Ratanatharathorn A, Aiello AE, Almli LM, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bierut LJ, Bisson J, Bradley B, Chen CY, Dalvie S, Farrer LA, Galea S, Garrett ME, Gelernter JE, Guffanti G, Hauser MA, Johnson EO, Kessler RC, Kimbrel NA, King A, Koen N, Kranzler HR, Logue MW, Maihofer AX, Martin AR, Miller MW, Morey RA, Nugent NR, Rice JP, Ripke S, Roberts AL, Saccone NL, Smoller JW, Stein DJ, Stein MB, Sumner JA, Uddin M, Ursano RJ, Wildman DE, Yehuda R, Zhao H, Daly MJ, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC. Molecular Psychiatry. 2018 Mar;23(3):666-673.
BDNF deletion or TrkB impairment in amygdala inhibits both appetitive and aversive learning.
Heldt SA, Zimmermann K, Parker K, Gaval M, Weinshenker D, Ressler KJ. The Journal of Neuroscience. 2014 Feb 12;34(7):2444-50.
Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood.
Dedic N, Pöhlmann ML, Richter JS, Mehta D, Czamara D, Metzger MW, Dine J, Bedenk BT, Hartmann J, Wagner KV, Jurik A, Almli LM, Lori A, Moosmang S, Hofmann F, Wotjak CT, Rammes G, Eder M, Chen A, Ressler KJ, Wurst W, Schmidt MV, Binder EB, Deussing JM. Molecular Psychiatry. 2018 Mar;23(3):533-543.
Alpha-adrenergic receptors in PTSD - failure or time for precision medicine?
Ressler KJ. New England Journal of Medicine. 2018 Feb 8;378(6):575-576.
PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus.
Stevens JS, Almli LM, Fani N, Gutman DA, Bradley B, Norrholm SD, Reiser E, Ely TD, Dhanani R, Glover EM, Jovanovic T, Ressler KJ. Proceedings of the National Academy of Sciences. 2014 Feb 25;111(8):3158-63.
Quantified Coexpression Analysis of Central Amygdala Subpopulations.
McCullough KM, Morrison FG, Hartmann J, Carlezon WA Jr, Ressler KJ. eNeuro. 2018 Feb 6.
Parental olfactory experience influences behavior and neural structure in subsequent generations.
Dias BG, Ressler KJ. Nature Neuroscience. 2014 Jan;17(1):89-96.
Expression of the PPM1F Gene Is Regulated by Stress and Associated With Anxiety and Depression.
Wingo AP, Velasco ER, Florido A, Lori A, Choi DC, Jovanovic T, Ressler KJ, Andero R. Biological Psychiatry. 2018 Feb 1;83(3):284-295.
Angiotensin Type 1 Receptor Inhibition Enhances the Extinction of Fear Memory.
Marvar PJ, Goodman J, Fuchs S, Choi DC, Banerjee S, Ressler KJ. Biological Psychiatry. 2013 Oct 3. pii: S0006-3223(13)00777
Perineuronal Nets in the Adult Sensory Cortex Are Necessary for Fear Learning.
Banerjee SB, Gutzeit VA, Baman J, Aoued HS, Doshi NK, Liu RC, Ressler KJ. Neuron. 2017 Jul 5;95(1):169-179.e3.
A randomized, double-blind evaluation of D-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in Iraq and Afghanistan War veterans.
Rothbaum BO, Price M, Jovanovic T, Norrholm SD, Gerardi M, Dunlop B, Davis M, Bradley B, Duncan EJ, Rizzo A, Ressler KJ. American Journal of Psychiatry. 2014 Jun 1;171(6):640-8.
Association of CRP genetic variation and CRP level with elevated PTSD symptoms and physiological responses in a civilian population with high levels of trauma.
Michopoulos V, Rothbaum AO, Jovanovic T, Almli LM, Bradley B, Rothbaum BO, Gillespie CF, Ressler KJ. American Journal of Psychiatry. 2015 Apr 172(4):353-62.
A role for Tac2, NkB, and Nk3 receptor in normal and dysregulated fear memory consolidation.
Andero R, Dias BG, Ressler KJ. Neuron. 2014 Jul 16;83(2):444-54.
Voxel-based morphometry predicts shifts in dendritic spine density and morphology with auditory fear conditioning.
Keifer OP Jr, Hurt RC, Gutman DA, Keilholz SD, Gourley SL, Ressler KJ. Nature Communications. 2015 Jul 7;6:7582.
Amygdala-Dependent Fear Memory Consolidation via miR-34a and Notch Signaling.
Dias BG, Goodman JV, Ahluwalia R, Easton AE, Andero R, Ressler KJ. Neuron. 2014 Aug 20;83(4):906-18.
Extinction reverses olfactory fear-conditioned increases in neuron number and glomerular size.
Morrison FG, Dias BG, Ressler KJ. Proceedings of the National Academy of Sciences. 2015 Oct 112(41):12846-51.
DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression.
Wingo AP, Almli LM, Stevens JJ, Klengel T, Uddin M, Li Y, Bustamante AC, Lori A, Koen N, Stein DJ, Smith AK, Aiello AE, Koenen KC, Wildman DE, Galea S, Bradley B, Binder EB, Jin P, Gibson G, Ressler KJ. Nature Communications. 2015 Dec 3;6:10106.