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  • The Ressler lab at Yerkes National Primate Research Center is focused on the molecular and cellular mechanisms of fear learning and the process of extinction of fear in mouse models. The primary objective of the work in the Ressler lab is to utilize the power of molecular genetics to understand the molecular biology, the neural circuitry, and the behavioral biology of fear and extinction of fear in mouse models.

  • Dr. Ressler is also a practicing psychiatrist with an interest in translational and clinical research on fear-based psychiatric disorders. During his clinical time, Dr. Ressler is co-director of a newly created Post-traumatic Stress Disorders Clinic at the Adult Outpatient Psychiatry Clinic at Grady Memorial Hospital.

  • We hope that by understanding how fear works in the mammalian brain in the laboratory, it will improve our understanding of and provide translational treatments and possibly prevention for fear-based disorders, such as Post-traumatic Stress Disorder, Phobic Disorders, and Panic Disorder.

In vivo knockdown of GAD67 in the amygdala disrupts fear extinction and the anxiolytic-like effect of diazepam in mice.
Heldt SA, Mou L, Ressler KJ. Transl Psychiatry. 2012 Nov 13;2:e181. doi: 10.1038/tp.2012.101. PubMed PMID: 23149445.
Mapping of the mouse olfactory system with manganese-enhanced magnetic resonance imaging and diffusion tensor imaging
Gutman DA, Magnuson M, Majeed W, Keifer OP Jr, Davis M, Ressler KJ, Keilholz S.  Brain Struct Funct. 2012 Apr 24
The Grady Trauma Project
This project aims to determine the relative contribution of genetic and trauma-related risk factors for Posttraumatic Stress Disorder (PTSD) in a cross-sectional study of a highly traumatized, low socioeconomic status, minority urban population.
Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies
Mehta D, Gonik M, Klengel T, Rex-Haffner M, Menke A, Rubel J, Mercer KB, Pütz B, Bradley B, Holsboer F, Ressler KJ, Müller-Myhsok B, Binder EB.  Arch Gen Psychiatry. 2011 Sep;68(9):901-10.