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  • The Ressler lab at Yerkes National Primate Research Center is focused on the molecular and cellular mechanisms of fear learning and the process of extinction of fear in mouse models. The primary objective of the work in the Ressler lab is to utilize the power of molecular genetics to understand the molecular biology, the neural circuitry, and the behavioral biology of fear and extinction of fear in mouse models.

  • Dr. Ressler is also a practicing psychiatrist with an interest in translational and clinical research on fear-based psychiatric disorders. During his clinical time, Dr. Ressler is co-director of a newly created Post-traumatic Stress Disorders Clinic at the Adult Outpatient Psychiatry Clinic at Grady Memorial Hospital.

  • We hope that by understanding how fear works in the mammalian brain in the laboratory, it will improve our understanding of and provide translational treatments and possibly prevention for fear-based disorders, such as Post-traumatic Stress Disorder, Phobic Disorders, and Panic Disorder.

Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning.
Choi DC, Gourley SL, Ressler KJ. Transl Psychiatry. 2012 Dec 18;2:e205. doi: 10.1038/tp.2012.128. PubMed PMID: 23250006.
Reduced neural activation during an inhibition task is associated with impaired fear inhibition in a traumatized civilian sample
Jovanovic T, Ely T, Fani N, Glover EM, Gutman D, Tone EB, Norrholm SD, Bradley B, Ressler KJ.  Cortex. 2012 Sep 5
Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies
Mehta D, Gonik M, Klengel T, Rex-Haffner M, Menke A, Rubel J, Mercer KB, Pütz B, Bradley B, Holsboer F, Ressler KJ, Müller-Myhsok B, Binder EB.  Arch Gen Psychiatry. 2011 Sep;68(9):901-10.
Ressler Lab Featured in Nature News
Stress: The roots of resilience
Most people bounce back from trauma — but some never recover. Scientists are trying to work out what underlies the difference.