canadian healthcare pharmacy

  • The Ressler lab at Yerkes National Primate Research Center is focused on the molecular and cellular mechanisms of fear learning and the process of extinction of fear in mouse models. The primary objective of the work in the Ressler lab is to utilize the power of molecular genetics to understand the molecular biology, the neural circuitry, and the behavioral biology of fear and extinction of fear in mouse models.

  • Dr. Ressler is also a practicing psychiatrist with an interest in translational and clinical research on fear-based psychiatric disorders. During his clinical time, Dr. Ressler is co-director of a newly created Post-traumatic Stress Disorders Clinic at the Adult Outpatient Psychiatry Clinic at Grady Memorial Hospital.

  • We hope that by understanding how fear works in the mammalian brain in the laboratory, it will improve our understanding of and provide translational treatments and possibly prevention for fear-based disorders, such as Post-traumatic Stress Disorder, Phobic Disorders, and Panic Disorder.

Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
Ressler KJ, Mercer KB, Bradley B, Jovanovic T, Mahan A, Kerley K, Norrholm SD, Kilaru V, Smith AK, Myers AJ, Ramirez M, Engel A, Hammack SE, Toufexis D, Braas KM, Binder EB, May V.  Nature. 2011 Feb 24;470(7335):492-7.
Fear extinction in traumatized civilians with posttraumatic stress disorder: relation to symptom severity.
Norrholm SD, Jovanovic T, Olin IW, Sands LA, Karapanou I, Bradley B, Ressler KJ.  Biol Psychiatry. 2011 Mar 15;69(6):556-63.
Neurosurgery to Modulate Anxiety via Genetics
Georgette Gafford, Kerry Ressler and their colleagues have developed an intriguing tool for studying CRF. In the places where CRF is produced in a mouse’s brain, they can take out the gene of their choice.
Mapping of the mouse olfactory system with manganese-enhanced magnetic resonance imaging and diffusion tensor imaging
Gutman DA, Magnuson M, Majeed W, Keifer OP Jr, Davis M, Ressler KJ, Keilholz S.  Brain Struct Funct. 2012 Apr 24