• The Ressler lab at Yerkes National Primate Research Center is focused on the molecular and cellular mechanisms of fear learning and the process of extinction of fear in mouse models. The primary objective of the work in the Ressler lab is to utilize the power of molecular genetics to understand the molecular biology, the neural circuitry, and the behavioral biology of fear and extinction of fear in mouse models.

  • Dr. Ressler is also a practicing psychiatrist with an interest in translational and clinical research on fear-based psychiatric disorders. During his clinical time, Dr. Ressler is co-director of a newly created Post-traumatic Stress Disorders Clinic at the Adult Outpatient Psychiatry Clinic at Grady Memorial Hospital.

  • We hope that by understanding how fear works in the mammalian brain in the laboratory, it will improve our understanding of and provide translational treatments and possibly prevention for fear-based disorders, such as Post-traumatic Stress Disorder, Phobic Disorders, and Panic Disorder.

Implications of memory modulation for post-traumatic stress and fear disorders.
Parsons RG, Ressler KJ. Implications of memory modulation for post-traumatic stress and fear disorders. Nat Neurosci. 2013 Jan 28;16(2):146-53. doi:10.1038/nn.3296. Epub 2013 Jan 28. PubMed PMID: 23354388.
Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies
Mehta D, Gonik M, Klengel T, Rex-Haffner M, Menke A, Rubel J, Mercer KB, Pütz B, Bradley B, Holsboer F, Ressler KJ, Müller-Myhsok B, Binder EB.  Arch Gen Psychiatry. 2011 Sep;68(9):901-10.
Epigenetic modulation of Homer1a transcription regulation in amygdala and hippocampus with pavlovian fear conditioning
Mahan AL, Mou L, Shah N, Hu JH, Worley PF, Ressler KJ.  J Neurosci. 2012 Mar 28;32(13):4651-9.
Reduced neural activation during an inhibition task is associated with impaired fear inhibition in a traumatized civilian sample
Jovanovic T, Ely T, Fani N, Glover EM, Gutman D, Tone EB, Norrholm SD, Bradley B, Ressler KJ.  Cortex. 2012 Sep 5